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The Hen and Egg Drawback of Combating One other Flu Pandemic

Céline Gounder, KFF Health News’ editor-at-large for public well being, appeared on “CBS Morning News” on May 30 to debate issues that the unfold of an avian flu virus has decimated flocks of birds, which can have an effect on customers’ provide of eggs. Eggs are a significant instrument within the manufacturing of vaccines that would assist shield folks from a hen flu outbreak.

Even a peep of stories a couple of new flu pandemic is sufficient to set scientists clucking about eggs.

They frightened about them in 2005, and in 2009, and so they’re worrying now. That’s as a result of tens of millions of fertilized hen eggs are nonetheless the principle ingredient in making vaccines that, hopefully, will shield folks towards the outbreak of a brand new flu pressure.

“It’s almost comical to be using a 1940s technology for a 21st-century pandemic,” mentioned Rick Bright, who led the Health and Human Services Department’s Biomedical Advanced Research and Development Authority (BARDA) through the Trump administration.

It’s not so humorous, he mentioned, when the at the moment stockpiled formulation towards the H5N1 hen flu virus requires two photographs and a whopping 90 micrograms of antigen, but gives simply middling immunity. “For the U.S. alone, it would take hens laying 900,000 eggs every single day for nine months,” Bright mentioned.

And that’s provided that the chickens don’t get contaminated.

The unfold of an avian flu virus has decimated flocks of birds (and killed barn cats and different mammals). Cattle in not less than 9 states and not less than three folks within the U.S. have been contaminated, sufficient to convey public well being consideration as soon as once more to the potential for a worldwide pandemic.

As of May 30, the one confirmed human circumstances of an infection had been dairy staff in Texas and Michigan, who skilled eye irritation. Two shortly recovered, whereas the third developed respiratory symptoms and was being handled with an antiviral drug at residence. The virus’s unfold into a number of species over an enormous geographic space, nonetheless, raises the menace that additional mutations may create a virus that spreads from human to human by means of airborne transmission.

If they do, prevention begins with the egg.


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To make uncooked materials for an influenza vaccine, virus is grown in tens of millions of fertilized eggs. Sometimes it doesn’t develop effectively, or it mutates to a level that the vaccine product stimulates antibodies that don’t neutralize the virus — or the wild virus mutates to an extent that the vaccine doesn’t work towards it. And there’s all the time the scary prospect that wild birds may carry the virus into the henhouses wanted in vaccine manufacturing.

“Once those roosters and hens go down, you have no vaccine,” Bright mentioned.

Since 2009, when an H1N1 swine flu pandemic swept all over the world earlier than vaccine manufacturing may get off the bottom, researchers and governments have been in search of options. Billions of {dollars} have been invested into vaccines produced in mammalian and bug cell traces that don’t pose the identical dangers as egg-based photographs.

“Everyone knows the cell-based vaccines are better, more immunogenic, and offer better production,” mentioned Amesh Adalja, an infectious illness specialist at Johns Hopkins University’s Center for Health Security. “But they are handicapped because of the clout of egg-based manufacturing.”

The corporations that make the cell-based influenza vaccines, CSL Seqirus and Sanofi, even have billions invested in egg-based manufacturing traces that they aren’t keen to switch. And it’s onerous in charge them, mentioned Nicole Lurie, HHS’ assistant secretary for preparedness and response beneath President Barack Obama who’s now an govt director of CEPI, the worldwide epidemic-fighting nonprofit.

“Most vaccine companies that responded to an epidemic — Ebola, Zika, covid — ended up losing a lot of money on it,” Lurie mentioned.

Exceptions had been the mRNA vaccines created for covid, though even Pfizer and Moderna have needed to destroy a whole bunch of tens of millions of doses of undesirable vaccine as public curiosity waned.

Pfizer and Moderna are testing seasonal influenza vaccines made with mRNA, and the federal government is soliciting bids for mRNA pandemic flu vaccines, mentioned David Boucher, director of infectious illness preparedness at HHS’ Administration for Strategic Preparedness and Response.

Bright, whose company invested a billion {dollars} in a cell-based flu vaccine manufacturing facility in Holly Springs, North Carolina, mentioned there’s “no way in hell we can fight an H5N1 pandemic with an egg-based vaccine.” But for now, there’s little alternative.

BARDA has stockpiled a whole bunch of 1000’s of doses of an H5N1-strain vaccine that stimulates the creation of antibodies that seem to neutralize the virus now circulating. It may produce tens of millions extra doses of the vaccine inside weeks and as much as 100 million doses in 5 months, Boucher advised KFF Health News.

But the vaccines at the moment within the nationwide stockpile aren’t an ideal match for the pressure in query. Even with two photographs containing six occasions as a lot vaccine substance as typical flu photographs, the stockpiled vaccines had been solely partly efficient towards strains of the virus that circulated when these vaccines had been made, Adalja mentioned.

However, BARDA is at the moment supporting two medical trials with a candidate vaccine virus that “is a good match for what we’ve found in cows,” Boucher mentioned.

Flu vaccine makers are simply beginning to put together this fall’s photographs however, ultimately, the federal authorities may request manufacturing be switched to a pandemic-targeted pressure.

“We don’t have the capacity to do both,” Adalja mentioned.

For now, ASPR has a stockpile of bulk pandemic vaccine and has recognized manufacturing websites the place 4.8 million doses might be bottled and completed with out stopping manufacturing of seasonal flu vaccine, ASPR chief Dawn O’Connell said on May 22. U.S. officers started attempting to diversify away from egg-based vaccines in 2005, when avian flu first gripped the world, and with added vigor after the 2009 fiasco. But “with the resources we have available, we get the best bang for our buck and best value to U.S. taxpayers when we leverage the seasonal infrastructure, and that’s still mostly egg-based,” Boucher mentioned.

Flu vaccine corporations “have a system that works well right now to accomplish their objectives in manufacturing the seasonal vaccine,” he mentioned. And with no monetary incentive, “we are going to be here with eggs for a while, I think.”

Arthur Allen:
aallen@kff.org,
@ArthurAllen202

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